Endocrine Abstracts

Introduction: Leptin is a well-known adipokine which has a critical role in the regulation of body weight, body fat mass, appetite, and food intakes. Energy-supplying nutrients such as carbohydrates is a dietary-related factor which has potential effects on plasma leptin levels. The effect of habitual carbohydrates intake on leptin gene expression was limited only in animal studies. The current study aimed to investigate the association of habitual carbohydrate intake with lep...

Background and aim: Apelin, as an adipokine, is encoded by the APLN gene. It is a key regulator in glucose and lipid metabolism and plays an important role in the pathogenesis of insulin resistance and type 2 diabetes. It seems that habitual dietary intake of carbohydrates including quality and quantity by chronic manipulating insulin concentration might have a distinguishing role in the prediction of apelin gene expression in adipose tissue, but there is no evidence in this r...

Introduction: Human fat mass and obesity-associated gene (FTO) gene expression are associated with body mass index and type 2 diabetes. It is unknown whether lifestyle factors, such as physical activity, can attenuate weight gain and obesity by contribution to the FTO gene regulation. The objective of the present study was to investigate the association between habitual physical activity and the FTO gene expression among morbid obese and non-obese subjects.<p class="abstex...

New evidence indicated that miRNAs may contribute to the regulation of energy balance and metabolic homeostasis, by controlling a wide range of metabolic pathways. miR-143 and miR-34a are the best studied among the miRNAs linked to adipose tissue regulation. Dietary intake, among many other environmental factors, is a key player that can induce epigenetic changes. The aim of the study was to investigate the association of the miR-143 and miR-34a expression in visceral and subc...

Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are key enzymes involved in intracellular degradation of triacylglycerols. The environmental factors and circulating biomarkers can affect the expression of ATGL and HSL in adipocytes among rats. To our knowledge, however, no information is known about the dietary and plasma fatty acids composition on gene expression of ATGL and HSL in human adipose tissue. We aimed to determine how fatty acid species measur...

In the current study, we aimed to illustrate determinants of VDR gene expression in visceral and subcutaneous adipose tissues among obese and morbidly obese adults. We gathered visceral and subcutaneous adipose tissues during an elective abdominal surgery form 33 morbidly obese (body mass index (BMI) >40 kg/m2) and 23 obese (BMI = 30–40 kg/m2) participants who were free of diabetes. Before the surgery, dietary intake, physical activity, anth...

Introduction and aim: Leptin is a hormone that mainly expressed and secreted in adipose tissues and has a number of important effects on regulation of body weight, energy expenditure, and thermogenesis. High intake of n-3 polyunsaturated fatty acids (PUFA) promotes reduced plasma concentration of triacylglycerol, glycerol, and free fatty acids, as well as metabolism of the epididymis. The aim of current study was to examine the association of n-3PUFA on leptin gene expression ...

Background and objective: Adipose tissue where energy homeostasis is regulated is now considered an endocrine organ. miRNAs may contribute to the regulation of energy balance and metabolic homeostasis, by controlling a wide range of metabolic pathways. miR-143 and miR-34a are the best studied among the miRNAs linked to adipose tissue regulation. Dietary intake, among many other environmental factors, is a key player that can induce epigenetic changes. The aim of the study was ...

Introduction: Adipocytokines secreted by adipose tissue are suggested to play a role in the development of obesity-related complications. Leptin is mainly produced and secreted by adipose tissue and appears as an important regulator of energy balance. The relationship between leptin levels and energy expenditure remain unclear. Energy expenditure related to physical activity (PA) is the most variable part of total energy expenditure. There is some evidence tha...

Introduction: The fat mass and obesity-associated gene (FTO) has been shown to be associated with obesity and might be affected by dietary factors. Long-term dietary intake of amino acids are capable to change adipose tissue metabolism through regulation of FTO production. This study aims to examining the association of dietary acidic and basic amino acids (AAs) with FTO gene expression in subcutaneous and visceral adipose tissues among non-diabetic adults.<p class="abstex...